Aqueous Extract from Cinnamomum zeylanicum (Lauraceae) Stem Bark Ameliorates Gentamicin-Induced Nephrotoxicity in Rats by Modulating Oxidative Stress and Inflammatory Markers

Nephropathies and especially nephrotoxicity have become one of the serious causes life-threatening conditions because intensive exposure to xenobiotic whether by environmental pollution or drug abuse. The present study was undertaken assess protective effects Cinnamomum zeylanicum stem bark aqueous extract (AECZ) on gentamicin-induced nephrotoxicity. AECZ prepared maceration in water tested orally at doses 200 400 mg/kg/day prevent nephropathies male Wistar rats. Gentamicin (100 mg/kg/day) administered for 14 consecutive days intraperitoneal route, concomitantly with silymarin (50 used as reference drug. Animal body weight monitored during treatment. After last treatment 14th day, animals were sacrificed. Blood collected evaluation hematological renal function biomarkers. homogenate kidney oxidative stress markers proinflammatory cytokines, while other fixed formaldehyde histopathological studies. decreased weight, serum total proteins, calcium level but increased kidneys’ relative creatinine, urea, uric acid. Moreover, levels reduced glutathione, catalase, superoxide dismutase activities decreased, an increase malondialdehyde, cytokines (TNF-α, IL-1β, IL-6), nitrites observed negative control group compared normal control. Histological analysis revealed presence tubular necrosis, glomerular degeneration, macrophage infiltration gentamicin-treated group. All these impairment parameters prevented treatments. has a effect against antioxidant anti-inflammatory potentials this may highly contribute its nephroprotective activity.